Antioxidant defenses in lung lining fluid of broilers: impact of poor ventilation conditions
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15 صفحه اولInhibiting Glutathione Metabolism in Lung Lining Fluid as a Strategy to Augment Antioxidant Defense
Glutathione is abundant in the lining fluid that bathes the gas exchange surface of the lung. On the one hand glutathione in this extracellular pool functions in antioxidant defense to protect cells and proteins in the alveolar space from oxidant injury; on the other hand, it functions as a source of cysteine to maintain cellular glutathione and protein synthesis. These seemingly opposing funct...
متن کاملA novel lung slice system with compromised antioxidant defenses.
In order to facilitate the study of oxidative stress in lung tissue, rat lung slices with impaired antioxidant defenses were prepared and used. Incubation of lung slices with the antineoplastic agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) (100 microM) in an amino acid-rich medium for 45 min produced a near-maximal (approximately 85%), irreversible inhibition of glutathione reductase, accom...
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ژورنال
عنوان ژورنال: Poultry Science
سال: 1998
ISSN: 0032-5791
DOI: 10.1093/ps/77.4.516